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1

CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model

Saima Hassan, Marguerite Buchanan, Kaushar Jahan, Adriana Aguilar-Mahecha, Louis Gaboury, William J. Muller, Yaqoob Alsawafi, Anna A. Mourskaia, Peter M. Siegel, Ombretta Salvucci, Mark Basik

Journal:

International Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 527 KB

english, 2011

2

Acute cyclophosphamide exposure has germ cell specific effects on the expression of stress response genes during rat spermatogenesis

Adriana Aguilar-Mahecha, Barbara F. Hales, Bernard Robaire

Journal:

Molecular Reproduction and Development

Year:

2001

Language:

english

File:

PDF, 187 KB

english, 2001

3

Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers

Sophie Hamel, Amélie Bouchard, Cristiano Ferrario, Saima Hassan, Adriana Aguilar-Mahecha, Marguerite Buchanan, Louise Quenneville, Wilson Miller, Mark Basik

Journal:

Breast Cancer Research and Treatment

Year:

2010

Language:

english

File:

PDF, 480 KB

english, 2010

4

Making personalized medicine a reality: the challenges of a modern translational research biopsy-driven program in an academic setting: the Segal Cancer Center experience

Adriana Aguilar-Mahecha, Zuanel Diaz, Marguerite Buchanan, Cristiano Ferrario, André Lisbona, Errol Camlioglu, Carole Séguin, Mark Basik

Journal:

Journal of Medicine and the Person

Year:

2011

Language:

english

File:

PDF, 272 KB

english, 2011

5

The stress response in gametes and embryos after paternal chemical exposures

Barbara F. Hales, Adriana Aguilar-Mahecha, Bernard Robaire

Journal:

Toxicology and Applied Pharmacology

Year:

2005

Language:

english

File:

PDF, 203 KB

english, 2005

6

Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Inhibiting CD4 Th17 T Cells in a CC Chemokine Ligand 2-Dependent Manner

Rafei, M., Campeau, P. M., Aguilar-Mahecha, A., Buchanan, M., Williams, P., Birman, E., Yuan, S., Young, Y. K., Boivin, M.-N., Forner, K., Basik, M., Galipeau, J.

Journal:

The Journal of Immunology

Year:

2009

Language:

english

File:

PDF, 663 KB

english, 2009

7

Development of reverse phase protein microarrays for the validation of clusterin, a mid-abundant blood biomarker

Adriana Aguilar-Mahecha, Christiane Cantin, Maureen O'Connor-McCourt, Andre Nantel, Mark Basik

Journal:

Proteome Science

Year:

2009

Language:

english

File:

PDF, 642 KB

english, 2009

8

Biopsies: next-generation biospecimens for tailoring therapy

Basik, Mark, Aguilar-Mahecha, Adriana, Rousseau, Caroline, Diaz, Zuanel, Tejpar, Sabine, Spatz, Alan, Greenwood, Celia M. T., Batist, Gerald

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2013

Language:

english

File:

PDF, 750 KB

english, 2013

9

Next-generation biobanking of metastases to enable multidimensional molecular profiling in personalized medicine

Diaz, Zuanel, Aguilar-Mahecha, Adriana, Paquet, Eric R, Basik, Mark, Orain, Michèle, Camlioglu, Errol, Constantin, André, Benlimame, Naciba, Bachvarov, Dimcho, Jannot, Guillaume, Simard, Martin J, Cha

Journal:

Modern Pathology

Year:

2013

Language:

english

File:

PDF, 601 KB

english, 2013

10

Testing devices or experimental systems? Cancer clinical trials take the genomic turn

Nelson, Nicole C., Keating, Peter, Cambrosio, Alberto, Aguilar-Mahecha, Adriana, Basik, Mark

Journal:

Social Science & Medicine

Year:

2014

Language:

english

File:

PDF, 285 KB

english, 2014

11

MC13-0077 Array CGH analysis of paired metastatic biopsies obtained pre-treatment and at resistance to FOLFOX-bevacizumab in metastatic CRC patients

Diaz, Z., Przybytkowski, E., Lan, C., McNamara, S., Aguilar-Mahecha, A., Camlioglu, E., Gologan, A., Batist, G., Basik, M.

Journal:

European Journal of Cancer

Year:

2013

Language:

english

File:

PDF, 52 KB

english, 2013

12

Contents

Diaz, Z., Przybytkowski, E., Lan, C., McNamara, S., Aguilar-Mahecha, A., Camlioglu, E., Gologan, A., Batist, G., Basik, M.

Journal:

Psychiatric Clinics of North America

Year:

2010

Language:

english

File:

PDF, 43 KB

english, 2010

13

Biopsies: next-generation biospecimens for tailoring therapy

Basik, Mark, Aguilar-Mahecha, Adriana, Rousseau, Caroline, Diaz, Zuanel, Tejpar, Sabine, Spatz, Alan, Greenwood, Celia M. T., Batist, Gerald

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2013

File:

PDF, 123 KB

2013

14

Microarrays as Validation Strategies in Clinical Samples: Tissue and Protein Microarrays

Aguilar-Mahecha, Adriana, Hassan, Saima, Ferrario, Cristiano, Basik, Mark

Journal:

Omics A Journal of Integrative Biology

Year:

2006

Language:

english

File:

PDF, 2.17 MB

english, 2006

15

Glycoproteomic Comparison of Clinical Triple-Negative and Luminal Breast Tumors

Hill, Jennifer J., Tremblay, Tammy-Lynn, Fauteux, François, Li, Jie, Wang, Edwin, Aguilar-Mahecha, Adriana, Basik, Mark, O’Connor-McCourt, Maureen

Journal:

Journal of Proteome Research

Year:

2015

Language:

english

File:

PDF, 2.52 MB

english, 2015

16

Effects of Acute and Chronic Cyclophosphamide Treatment on Meiotic Progression and the Induction of DNA Double-Strand Breaks in Rat Spermatocytes

Aguilar-Mahecha, A.

Journal:

Biology of Reproduction

Year:

2005

Language:

english

File:

PDF, 448 KB

english, 2005

17

Chronic Cyclophosphamide Treatment Alters the Expression of Stress Response Genes in Rat Male Germ Cells

Aguilar-Mahecha, A.

Journal:

Biology of Reproduction

Year:

2002

Language:

english

File:

PDF, 455 KB

english, 2002

18

Technology & tools development

Pefani, E., Panoskaltsis, N., Mantalaris, A., Georgiadis, M. C., Pistikopoulos, E. N., Aguilar-Mahecha, A., Lafleur, J., Seguin, C., Rosenbloom, M., Przybytkowski, E., Pelmus, M., Diaz, Z., Batist, G.

Journal:

Annals of Oncology

Year:

2012

Language:

english

File:

PDF, 200 KB

english, 2012

19

Expression of Stress Response Genes in Germ Cells During Spermatogenesis

Aguilar-Mahecha, A.

Journal:

Biology of Reproduction

Year:

2001

Language:

english

File:

PDF, 198 KB

english, 2001

20

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

Dupuy, Fanny, Tabariès, Sébastien, Andrzejewski, Sylvia, Dong, Zhifeng, Blagih, Julianna, Annis, Matthew G., Omeroglu, Atilla, Gao, Dongxia, Leung, Samuel, Amir, Eitan, Clemons, Mark, Aguilar-Mahecha,

Journal:

Cell Metabolism

Year:

2015

Language:

english

File:

PDF, 3.65 MB

english, 2015

21

29P * GENOMIC ANALYSIS OF DRUG RESISTANT TRIPLE NEGATIVE BREAST CANCERS: A TRANSLATIONAL BIOPSY STUDY

Aguilar-Mahecha, A., Przybytkowski, E., Ahmadzadeh, E., Lafleur, J., Alirezaie, N., Mihalcioiu, C., Robidoux, A., Roy, J., Majewski, J., Basik, M.

Journal:

Annals of Oncology

Year:

2013

Language:

english

File:

PDF, 31 KB

english, 2013

22

The identification of challenges in tissue collection for biomarker studies: the Q-CROC-03 neoadjuvant breast cancer translational trial experience

Aguilar-Mahecha, Adriana, Lafleur, Josiane, Pelmus, Manuela, Seguin, Carole, Lan, Cathy, Discepola, Federico, Kovacina, Bojan, Christodoulopoulos, Rosa, Salvucci, Ombretta, Mihalcioiu, Catalin, Roy, J

Journal:

Modern Pathology

Year:

2017

Language:

english

File:

PDF, 2.04 MB

english, 2017

23

Immuno-MALDI (iMALDI) for quantifying AKT1 and AKT2 in breast and colorectal cancer cell lines and tumors

Popp, Robert, Li, Huiyan, LeBlanc, André, Mohammed, Yassene, Aguilar-Mahecha, Adriana, Chambers, Andrew G., Lan, Cathy, Poetz, Oliver, Basik, Mark, Batist, Gerald, Borchers, Christoph H.

Journal:

Analytical Chemistry

Year:

2017

Language:

english

File:

PDF, 1.10 MB

english, 2017

24

The Effect of Pre-Analytical Variability on the Measurement of MRM-MS-Based Mid- to High-Abundance Plasma Protein Biomarkers and a Panel of Cytokines

Aguilar-Mahecha, Adriana, Kuzyk, Michael A., Domanski, Dominik, Borchers, Christoph H., Basik, Mark, Krauss-Etschmann, Susanne

Journal:

Year:

2012

Language:

english

File:

PDF, 299 KB

english, 2012

25

A study of pre-analytical variables and optimization of extraction method for circulating tumor DNA measurements by digital droplet PCR

Cavallone, Luca, Aldamry, Mohammed, Lafleur, Josiane, Lan, Cathy, Gonzalez Ginestet, Pablo, Alirezaie, Najmeh, Ferrario, Cristiano, Aguilar-Mahecha, Adriana, Basik, Mark

Journal:

Cancer Epidemiology Biomarkers & Prevention

Year:

2019

Language:

english

File:

PDF, 862 KB

english, 2019

26

An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy

Darini, Cedric, Ghaddar, Nour, Chabot, Catherine, Assaker, Gloria, Sabri, Siham, Wang, Shuo, Krishnamoorthy, Jothilatha, Buchanan, Marguerite, Aguilar-Mahecha, Adriana, Abdulkarim, Bassam, Deschenes,

Journal:

Nature Communications

Year:

2019

Language:

english

File:

PDF, 1.72 MB

english, 2019

27

A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability

Sirois, Isabelle, Aguilar-Mahecha, Adriana, Lafleur, Josiane, Fowler, Emma, Vu, Viet, Scriver, Michelle, Buchanan, Marguerite, Chabot, Catherine, Ramanathan, Aparna, Balachandran, Banujan, Légaré, Sté

Journal:

Molecular Cancer Research

Year:

2019

File:

PDF, 2.21 MB

2019

28

L6.2 Biopsy-Driven Trials to Identify Biomarkers of Therapeutic Resistance: Biospecimen Collection and Processing to Enable Multi-Dimensional Analysis

Batist, G., Assouline, S., Camlioglu, E., TÃªtu, B., Spatz, A., Diaz, Z., Aguilar-Mahecha, A., Basik, M.

Journal:

Annals of Oncology

Year:

2012

File:

PDF, 104 KB

2012

29

P3.02 Challenges in The Implementation of a Translational Research Biopsy-Driven Trial to Study Drug Resistance in Triple Negative Breast Cancer Patients

Aguilar-Mahecha, A., Lafleur, J., Seguin, C., Rosenbloom, M., Przybytkowski, E., Pelmus, M., Diaz, Z., Batist, G., Basik, M.

Journal:

Annals of Oncology

Year:

2012

File:

PDF, 76 KB

2012

30

P3.07 Building the Organization Framework for Biopsy-Driven Translational Research: The Quebec Clinical Research Organization in Cancer (Q-Croc) Experience

Diaz, Z., Gagnon-Kugler, T., Rousseau, C., Aguilar-Mahecha, A., Alcindor, T., Aloyz, R., Assouline, S., Basik, M., Bachvarov, D., BÃ©langer, L., Camlioglu, E., Cartillone, M., Chabot, B., Christodoulo

Journal:

Annals of Oncology

Year:

2012

File:

PDF, 68 KB

2012

31

Using two peptide isotopologues as internal standards for the streamlined quantification of low-abundance proteins by immuno-MRM and immuno-MALDI

Ibrahim, Sahar, Froehlich, Bjoern, Aguilar-Mahecha, Adriana, Aloyz, Raquel, Poetz, Oliver, Basik, Mark, Batist, Gerald, Zahedi, Rene P., Borchers, Christoph H

Journal:

Analytical Chemistry

Year:

2020

File:

PDF, 816 KB

2020

32

Breast cancer mammospheres secrete Adrenomedullin to induce lipolysis and browning of adjacent adipocytes

ParÃ©, Martin, Darini, CÃ©dric Y., Yao, Xi, Chignon-Sicard, BÃ©rengÃ¨re, Rekima, Samah, Lachambre, Simon, Virolle, Virginie, Aguilar-Mahecha, Adriana, Basik, Mark, Dani, Christian, Ladoux, Annie

Journal:

Year:

2020

File:

PDF, 8.31 MB

2020

33

Prognostic and predictive value of circulating tumor DNA during neoadjuvant chemotherapy for triple negative breast cancer

Cavallone, Luca, Aguilar-Mahecha, Adriana, Lafleur, Josiane, Brousse, Susie, Aldamry, Mohammed, Roseshter, Talia, Lan, Cathy, Alirezaie, Najmeh, Bareke, Eric, Majewski, Jacek, Ferrario, Cristiano, Has

Journal:

Scientific Reports

Year:

2020

File:

PDF, 2.39 MB

2020